Session Index

Biophotonics and Biomedical Imaging

Biophotonics and Biomedical Imaging I
Thursday, Dec. 3, 2020  13:15-14:45
Presider: Prof. Sheng-Hao Tseng
Prof. Chia-Wei Sun
Room: 6AB Room 526
13:15 - 13:30 Manuscript ID.  0045
Paper No.  2020-THU-S0601-O001
Meng-Shan Wu
Award Candidate
Development of a catheter based optical coherence tomography system for the early detection of cervical precancerous lesions
Meng-Shan Wu;Yi-Chun Wu;Ting-Yen Tsai;Ching-Yu Wang;Chuan-Bor Chueh;Ting-Hao Chen;You-Nan Tsai;Meng-Tsan Tsai;Chun-Chieh Wang;Hsiang-Chieh Lee

In this study, we have developed a catheter-based OCT system allowing volumetric imaging of the cervix. The rotary junction and catheter are custom-designed to tailor the aforementioned biomedical applications. Preliminary imaging results of the human fingertip were shown to demonstrate the imaging capability of the developed imaging system.

13:30 - 13:45 Manuscript ID.  0051
Paper No.  2020-THU-S0601-O002
Yi-Chun Wu
Award Candidate
Comparison of vascular image quality with different sweep rate laser light source based on variable interscan time analysis in optical coherence tomography angiography skin imaging
Yi-Chun Wu;Ting-Hao Chen;Ting-Yen Tsai;Chuan-Bor Chueh;Yin-Peng Huang;Meng-Tsan Tsai;Yoshiaki Yasuno;Hsiang-Chieh Lee

We have developed a swept-source OCT system using two 1060 nm wavelength-swept lasers with a sweep rate of 100,000 and 200,000 A-scans/sec to reconstruct optical coherence tomography angiography (OCTA) images. Preliminary results of the OCTA images of the mouse ear skin are presented in this paper.

13:45 - 14:00 Manuscript ID.  0057
Paper No.  2020-THU-S0601-O003
Chen-Yu Hung
Award Candidate
Snail-regulated biomechanical properties of head and neck squamous cell carcinoma cells prompt cancer metastasis
Chen-Yu Hung;Han-Ying Cheng;Jean-Cheng Kuo;Ming-Tzo Wei;Muh-Hwa Yang;Arthur Chiou;Yin-Quan Chen

We show that the epithelial-mesenchymal transition (EMT) factor, Snail, promotes the invasion capability of head and neck squamous cell carcinoma (HNSCC) cells by increasing cell traction forces and decreasing the nuclear stiffness, associated with the increment of cell focal adhesion and decrement of lamin B1 expression.

14:00 - 14:15 Manuscript ID.  0122
Paper No.  2020-THU-S0601-O004
Te-Hsin Chen
Award Candidate
Wide-field Interferometric Photothermal Microscopy for Quantitative Absorption Imaging
Te-Hsin Chen;Yu-Chien Huang;Jz-Yuan Juo;Shi-Wei Chu;Chia-Lung Hsieh

Light absorption is common in biological specimens which potentially serves as a unique contrast mechanism for microscope imaging especially when detecting non-fluorescent targets. We present a wide-field photothermal imaging technique that measures the local heat through interference and demonstrate absorption imaging of single metallic nanoparticles, as small as 5 nm.

14:15 - 14:30 Manuscript ID.  0230
Paper No.  2020-THU-S0601-O005
Diannata Rahman Yuliansyah
Award Candidate
Deep Learning Approach for NIR Optical Tomography
Diannata Rahman Yuliansyah;Min-Chun Pan;Nazish Murad

We develop a deep learning algorithm as an alternative to the existing Tikhonov regularization, relying on the idea of sensor-domain to image-domain transformation. U-net with skip connections is used to extract the features and obtain the contrast image. The output is obtained by multiplying contrast images with the background coefficients.

14:30 - 14:45 Manuscript ID.  0496
Paper No.  2020-THU-S0601-O006
Benedictus Yohanes Bagus Widhianto
Award Candidate
Bidirectional Feedback Broadband Coupler for OCT On-Chip Based Interferometer
Benedictus Yohanes Bagus Widhianto;Shih-Hsiang Hsu

The performance of interferometer for optical coherence tomography (OCT) such as flatness and broadband are important to maintain the axial resolution and sensitivity. We develop a broadband coupler using numerical optimization to obtain a broadband flat response with more than 180 nm bandwidth from a transmission and multiple reflection.