Session Index

Bio-lasers are emerging technology for next generation biochemical detection and biophotonic applications. Recently, laser-based detection has been exploited as a novel tool in biosensing due to their capability to amplify subtle changes in the gain media caused by underlying biological processes. Laser emission has unique merits over fluorescence, including threshold-gated emission, narrow linewidth, and strong intensity, leading to ultrasensitive detection of intracellular dynamics, and superior contrast for higher spectral/spatial resolution imaging. In this talk, I will introduce the recent advances of biolasers in cells, tissues, and neuronal networks, by using several types of micro laser cavities, such as optofluidic ring resonators and high-Q Fabry-Pérot mirrors. Next, we demonstrate the possible implementation of biolasers into an automated lasing system for systematic and statistical analysis, including an integrated cellular laser array device and laseremission microscopy for cancer screening and immuno-diagnosis. Furthermore, optical recording of calcium transients during spontaneous neuronal activities was first demonstrated via neuron lasers with a significantly improved sensitivity, not only for monitoring neuronal network dynamics but an ultra-sensitive detection method for brain-on-chip applications and neuro-analysis. Finally, discussion and outlook is made on the strategies through biolasers and to pioneer novel on-chip devices for future clinical diagnosis, prognosis, and fundamental research in biomedicine.

 

Light is not only for human vision but may also be a non-pharmacological method to improve the sleep cycle and quality life of people who have to live with dementia. Using LEDs, we have designed a 24-hour lighting timetable to simulate changes in daytime spectra for installation in long-term care.

 

A highly sensitive open-cavity fiber Fabry-Pérot interferometer (FPI) sensor is proposed by splicing an etched MMF with a HCF through a large offset of 50m. The measured refractive index and pressure sensing sensitivities are 1313.2 nm/RIU and 25.33 pm/psi, respectively, with very good linearity.

 

We deform a honeycomb lattice by shrunken or expanded the structure to induce the band inversion, which leads to a topological transition. At the boundary of nontrivial and trivial topological structure, we numerically demonstrate the characteristics of one-way propagation.

 

The stray light intensity arc of a retinal image in a fundus camera is analyzed. Besides the optimization of the hole mirror design, the impact of the hole mirror chamfer on the stray light intensity arc is also analyzed to preserve a clear retinal image in a fundus camera production.